By Gilbert N Ling
Unique 1963 evaluation via Jay Jacobs, MD:
A actual concept of the residing kingdom: The Association-Induction speculation. by means of GILBERT Ning LING, B.Sc., PH.D., Director of the dept of Molecular Biology, Pennsylvania Hospital.
Cloth, Pp. 680, with illustrations. Blaisdell Publishing Co.,A department of Random condominium. Inc., big apple, London, 1962.
The writer has been famous in his box for 15 years. His paintings is praised via his friends, together with Dr. C. N. Yang, a Nobel Laureate in Physics. This ebook was once written to coordinate actual chemistry, biochemistry and body structure, and clarify a few of the intricacies of residing tissue.
The contents are on such a complicated point that these conversant in one point will be baflled by way of others. to help in overcoming this hassle and to bridge the space among clinical disciplines there's a thesaurus of seventy one pages.
Unfortunately, the mathematical calculations in a few parts are too advanced for somebody who has now not had really expert training.
The variety of topics is vast; habit of Ions, nonelectrolytes and proteins; mobile potentials and permeabillty; excitatton, contraction and inhibition; the activities or enzymes, hormones, and medicine; progress and neoplasm. The author's "association-induction" speculation is drawn upon to give an explanation for the phenomena or chemical motion in dwelling tissue. This speculation states that the associatlon among proteins and interacting debris is significantly diversified in vivo and In vitro, and that the first functionality of the polarizable resonating chain of a protein is to supply a motor vehicle for the transmission of an inductive effect.
The booklet includes many tables, graphs, diagrams and mathematical calculations to aid its theses. The bibliography and references are extensive.
Every general practitioner may still learn a few parts of this e-book, to work out how some distance the fundamental scientists have are available knowing the habit of dwelling tissue. it truly is of worth largely as a reference publication to these whose paintings is on the easy technological know-how point.
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Additional info for A Physical Theory of the Living State the association-induction hypothesis
Micellar aggregates 17 B. 4. Association of Counterions in True Fixed-Charge Systems 22 A. The effects of energy and entropy on dissociation phenomena 23 (I) The configurational entropy of dissociation in a fixed-charge system 25 (2) The rotational entropy of dissociation in a :fixed-charge system 27 (3) The effect of the adsorption energy on ionic association 29 B. Nonliving three-dimensional fixed-charge systems 29 (1) Exchange resins 29 (2) Ion-selectivity properties of other nonliving fixed-charge systems 32 C.
To understand this, it is necessary to examine the nature of the inductive effect. INTRODUCTION xxxiii From organic chemistry we know that the effective charge carried by a polar group on an organic molecule may be varied by altering other chemical groupings in the molecule. For example, acetic acid, CH 3COOH, is a weak acid, while trichloroacetic acid, ClsCCOOH, the well-known protein denaturant, is a very strong acid. Yet both have the same functional COOH group. The substitution of the three hydrogen atoms for the more electronegative (having greater power to draw electrons toward themselves) chlorine atoms effectively diminishes the negative charge of the distant carboxyl group.
1. THE EFFECT OF MICELLE FORMATION ON CONDUCTANCE. The CUrVeS show the total equivalent conductance A. and the transport number of the paraffin chain cations t+ of cetylpyridinium • and cetyltrimethylammonium • bromides at 35°C. The inflection 1 marks the critical point for micelle formation with its associated charge fixation. Cationic transfer numbers were determined by the moving boundary method. (Figure after G. S. 3, agrees perfectly with this view. Similar dependence of the critical concentration of dodecyl sulfate on the nature of the alkali-metal countercation, K+, Na+, and so on, has also been reported by Meguro et al.