By Frank J. Dixon
Study Institute of Scripps hospital, l. a. Jolla. examine within the box. For investigators. 19 participants, 6 U.S.
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Extra resources for Advances in Immunology, Vol. 64
And Ichihara, A. (1992). Proteasomes: Protein and gene structures. New Biol. 4, 173-187. , and Ichihara, A. (1994). ATP- and antizyme-dependent endoproteolysis of ornithine decarbovlase to oligopeptides by the 26s proteasome. J. Biol. Chem. 269,17382-17385. Townsend, A,, and Trowsdale, J. (1993). Transporter associated with antigen processing. Sem. Cell Biol. 4, 53-61. , and Snith, G. (1988). Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccina-infected cells is overcome by enhanced degradation of antigen.
Srivastava et al. (1994) proposed that hsps play an essential role in transfer of antigenic peptides from the proteasome to the TAP transporter (Fig. 6). A similar model was also proposed by Rammensee et al. (1995) and H. Udono et al. (personal communication). , 1994, for details). , 1991). , 1993). In addition, grp9dgp96, a family of hsp90s, has been shown to have a similar tumorrejecting effect, demonstrating intrinsic ATPase activity and the ability to bind to several peptides (Li and Srivastava, 1993).
Mott, J. , Prammik, B. , Moomaw, C. , Afendis, S. , DeMartino, G. , and Slaughter, C. A. (1994). PA28, an activator of the 20s proteasome, is composed of two nonidentical but homologous subunits. J. Biol. Chem. 269, 31466-31471. , and Ichihara, A. (1992). Ornithine decarboxylase is degraded by the 26s proteasome without ubiquitination. Nature 360, 597-599. , Inhlenfeldt, H. , and Eichmann, K. (1995). Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules.