Download PDF by Wilson Golder N.: AHFS Drug Information 2004

By Wilson Golder N.

Supplies scientific scholars 500 questions, solutions, and reasons to organize for the biochemistry and genetics sections of the USMLE Step 1. the recent variation contains many new questions within the two-step medical structure to simulate the USMLE Step 1.

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A major toxin of the death-cap mushroom is the hepatotoxic octapeptide α-amanitin, which inhibits a. b. c. d. e. DNA primase RNA nuclease DNA ligase RNA polymerase RNA/DNA endonuclease 44. The consensus sequence 5′ TATAAAA 3′ found in eukaryotic genes is quite similar to a consensus sequence observed in prokaryotes. It is important as the a. b. c. d. e. Only site of binding of RNA polymerase III Promoter for all RNA polymerases Termination site for RNA polymerase II Major binding site of RNA polymerase I First site of binding of a transcription factor for RNA polymerase II 45.

Xeroderma pigmentosum (278700) appears to be due to the inability of an excision-repair system to remove thymine dimers, which are formed on exposure of DNA to ultraviolet radiation. This results in a deficiency in the ability to repair the damaged DNA. Mutagenesis by this mechanism is presumably the basis for the multiple neoplasms that occur in patients who have this disease. 21. The answer is e. (Murray, pp 412–434. Scriver, pp 3–45. Sack, pp 3–29. ) Double-stranded DNA is arranged in a double helix as originally deduced by Watson and Crick.

E. qxd 18 11/14/01 10:36 AM Page 18 Biochemistry and Genetics 27. Which of the following statements correctly describes the recombinant DNA tool known as plasmids? a. b. c. d. e. They are found more commonly in viruses than in bacteria They are single-stranded circles They sometimes enhance bacterial susceptibility to antibiotics They sometimes enhance bacterial resistance to antibiotics They are too small to be useful as vectors for the cloning of mammalian DNA segments 28. Which of the following molecules is found in a nucleoside?

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